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Updated: Jan 7, 2026

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Published on: January 7, 2018
The link between insulin resistance and mobility limitation in older persons
Virginia Boccardi, Giuseppe Paolisso1
1Department of Internal Medicine, Surgical, Neurological, Metabolic Disease and Geriatric Medicine. Second University of Naples; Naples, Italy. giuseppe.paolisso@unina2.it.
Abstract:
In this report we will provide additional insight on the individual features of age-related causes of mobility limitation, explaining why insulin resistance, related to lower muscle functioning, sub-inflammation and hormonal changes, may contribute to its onset and sustain it. According to the recent literature, the same factors playing a role in the onset and maintenance of insulin resistance are related to mobility limitation. Thus, the presence of insulin resistance can be considered a biomarker of susceptibility to mobility limitation among older persons. All described factors related to both conditions are strictly intertwined. Therefore, the identification and correction of a single factor is difficult to convert into clinical practice. Instead, insulin resistance may be considered not only an early biological marker, but also a predictive and modifiable marker of mobility limitation. Thus, interventions aimed at correcting insulin resistance may have a potential role in preventing or at least slowing down functional decline in the elderly population, promoting a better quality of life and potentially extending the "healthspan".
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