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Updated: May 7, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

Modeling the allosteric modulation of CCR5 function by Maraviroc.

Bernard Lagane, Javier Garcia-Perez, Esther Kellenberger

    Drug Discovery Today. Technologies
    |September 21, 2013
    PubMed
    Summary

    Maraviroc, a CC chemokine receptor 5 (CCR5) antagonist, is used for HIV treatment. Molecular modeling studies enhance understanding of its action and guide future drug development for improved efficacy and CCR5 function preservation.

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