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Generalized acanthosis nigricans without systemic disease associated.

Rafael Denadai¹, Ricardo Martinhao Souto, Mariam Patricia Auada-Souto

¹School of Medical Sciences, Universidade de Marilia.

Dermatology Online Journal

|September 21, 2013

Summary

Generalized acanthosis nigricans, a skin condition, is usually linked to cancer in adults. This report details a rare case in a 17-year-old without underlying systemic disease.

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Area of Science:

Dermatology
Endocrinology
Oncology

Background:

Acanthosis nigricans is a skin condition marked by velvety hyperpigmentation and thickening, typically affecting flexural areas.
The generalized form is often associated with malignancy in adults, but is rare in children and adolescents without systemic disease.

Observation:

This report describes an unusual case of generalized acanthosis nigricans in a 17-year-old patient.
The patient presented with characteristic skin changes affecting flexural areas.

Findings:

Extensive clinical, laboratory, and imaging investigations were conducted.
No underlying systemic disease or malignancy was identified as the cause of the acanthosis nigricans.

Implications:

This case highlights that generalized acanthosis nigricans can occur in adolescents without associated systemic disease.
It underscores the importance of thorough investigation but also acknowledges rare idiopathic presentations.
Further research may be needed to understand the mechanisms behind idiopathic generalized acanthosis nigricans in young individuals.