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Related Concept Videos

Cochran's Q Test01:17

Cochran's Q Test

Cochran's Q Test is a nonparametric statistical test used to determine if there are potential differences in the outcomes of three or more related groups on a binary (yes/no) or dichotomous outcome. It is essentially an extension of the McNemar Test, which is limited to two related samples - Cochran's Q test can handle three or more related samples, making it more versatile in scenarios where subjects are measured under multiple conditions. The test statistic follows a Chi-Square distribution,...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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The Scientific Method01:32

The Scientific Method

The scientific method is a detailed, empirical problem-solving process used by biologists and other scientists. This iterative approach involves formulating a question based on observation, developing a testable potential explanation for the observation (called a hypothesis), making and testing predictions based on the hypothesis, and using the findings to create new hypotheses and predictions.
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Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
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Statistical Methods for Analyzing Epidemiological Data

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Updated: May 7, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
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The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Cochrane methods--twenty years experience in developing systematic review methods.

Jackie Chandler1, Sally Hopewell

  • 1The Cochrane Collaboration, Oxford, UK. jchandler@cochrane.org.

Systematic Reviews
|September 21, 2013
PubMed
Summary
This summary is machine-generated.

The Cochrane Collaboration, celebrating 20 years, pioneered systematic review methods for synthesizing healthcare intervention evidence. This special issue details their methods development and future directions in evidence synthesis.

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Last Updated: May 7, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Area of Science:

  • Health Research Methods
  • Evidence Synthesis
  • Systematic Reviews

Background:

  • The Cochrane Collaboration has significantly influenced scientific methodology over two decades.
  • Systematic reviews are crucial for synthesizing research evidence, particularly from randomized trials.
  • The focus is on answering questions regarding the effects of healthcare interventions.

Observation:

  • This special issue presents a series of articles detailing the evolution of systematic review methods within The Cochrane Collaboration.
  • The development of review methods by the Collaboration has been extensive and profound.
  • The impact of Cochrane Review methodologies on the field of evidence synthesis is discussed.

Findings:

  • The Cochrane Collaboration's methods have been pivotal in advancing systematic reviewing.
  • The series explores the historical development and impact of these evidence synthesis techniques.
  • The breadth and depth of methods development within the Collaboration are highlighted.

Implications:

  • Understanding the development of Cochrane Review methods provides insight into best practices for evidence synthesis.
  • The discussion acknowledges the Collaboration's contribution within the broader field of evidence synthesis.
  • Future directions for the evolution of systematic review methods are considered for Cochrane Reviews.