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Updated: May 7, 2026
Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
Self-supported fibrin-polyvinyl alcohol interpenetrating polymer networks: an easily handled and rehydratable
Laurent Bidault1, Marie Deneufchatel, Cédric Vancaeyzeele
1Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules (Errmece), ‡Laboratoire de Physicochimie des Polymères et des Interfaces (LPPI), Institut des Matériaux, University of Cergy-Pontoise , 95000 Cergy-Pontoise, France.
Abstract:
A fibrin hydrogel at physiological concentration (5 mg/mL) was associated with polyvinyl alcohol (PVA) inside an interpenetrating polymer networks (IPN) architecture. Previously, PVA has been modified with methacrylate functions in order to cross-link it by free-radical polymerization. The fibrin network was synthesized by the enzymatic hydrolysis of fibrinogen by thrombin. The resulting self-supported materials simultaneously exhibit the properties of the fibrin hydrogel and those of the synthetic polymer network. Their storage modulus is 50-fold higher than that of the fibrin hydrogel and they are completely rehydratable. These materials are noncytotoxic toward human fibroblast and the fibrin present on the surface of PVAm-based IPNs favors cell development.
