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Related Experiment Video

Updated: May 7, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Optimizing nutrition in preterm infants.

Bai-Horng Su1

  • 1Department of Neonatology, China Medical University Children's Hospital, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan.

Pediatrics and Neonatology
|September 21, 2013
PubMed
Summary
This summary is machine-generated.

Extrauterine growth restriction affects many very preterm infants, increasing neurodevelopmental risks. Early, aggressive nutrition, including protein and energy, improves growth and is crucial for better outcomes.

Keywords:
early aggressive nutritionextrauterine growth restriction (EUGR)very preterm infants

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Last Updated: May 7, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

Area of Science:

  • Neonatalogy
  • Pediatric Nutrition
  • Developmental Pediatrics

Background:

  • Extrauterine growth restriction (EUGR) is prevalent in very preterm infants, with incidence varying widely (43-97%).
  • EUGR is linked to adverse neurodevelopmental outcomes.
  • Inadequate postnatal nutrition, characterized by protein and energy deficits in the neonatal intensive care unit (NICU), contributes significantly to growth failure.

Purpose of the Study:

  • To review the impact of nutrition on extrauterine growth restriction in very preterm infants.
  • To highlight the association between early nutrition and long-term developmental outcomes.
  • To discuss current nutritional strategies and areas for future research.

Main Methods:

  • Review of existing literature on neonatal nutrition and growth outcomes in preterm infants.
  • Analysis of the relationship between protein and energy intake and neurodevelopmental results.
  • Examination of different nutritional approaches, including parenteral, enteral, and post-discharge feeding.

Main Results:

  • First-week protein and energy intake correlate with 18-month developmental outcomes.
  • Early aggressive nutritional support (parenteral and enteral) is well-tolerated and promotes growth.
  • Optimizing protein-to-energy ratios may enhance lean mass accretion.

Conclusions:

  • Optimizing nutritional strategies is essential for improving growth and neurodevelopmental outcomes in very preterm infants.
  • Continued appropriate nutrition, including fortified human milk or specialized formulas, is vital during hospitalization and after discharge.
  • Further research is needed to refine nutritional requirements and assess long-term effects.