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Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case

Jos G M Bessems1, Liesbeth Geraets

  • 1National Institute for Public Health and the Environment (RIVM), P.O. Box 1, NL-3720 BA Bilthoven, The Netherlands.

Regulatory Toxicology and Pharmacology : RTP
|September 21, 2013
PubMed

Keywords:
ADMEAUCAbsorptionBMDLBioavailabilityC,t-curveNOAELRisk assessmentRisk characterisationRoute-to-route extrapolationSpecies selectionTKToxicokineticsabsorption, distribution, metabolism and excretionarea under the blood/plasma concentration time curvebenchmark dose lower limitblood/plasma concentration-time curveno-observed-adverse-effect leveltoxicokinetics

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