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Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

Jordi Heijman1, Matthias Dewenter, Ali El-Armouche

  • 1Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany.

Journal of Molecular and Cellular Cardiology
|September 21, 2013
PubMed

Keywords:
A-kinase-anchoring proteinAFAKAPAPAtrial fibrillationCKIP-1Ca(2+)/calmodulin-dependent protein kinase type-IICaMKIIDephosphorylationHFHeart failureI(Ca,L)I(K,ACh)I(K1)I(Kr)I(Ks)I(Kur)I(Na)I(NaK)L-type Ca(2+)-currentNCX1Na(+)-currentNa(+)–Ca(2+) exchangerNa(+)–K(+)-ATPase currentOAPDE4D3PKAPKCPLBPP1PP2AProtein phosphatasesRyR2SERCA2aSRTnIacetylcholine-dependent inward-rectifier K(+)-currentaction potentialatrial fibrillationbasal inward-rectifier K(+)-currentcMyBP-Ccardiac myosin-binding protein-Ccasein kinase-2 interacting protein-1heart failureokadaic acidphosphodiesterase-4D3phospholambanprotein kinase-Aprotein kinase-Cprotein phosphatase type-1protein phosphatase type-2Arapid delayed-rectifier K(+)-currentryanodine receptor type-2sarcoplasmic reticulumsarcoplasmic reticulum Ca(2+)-ATPaseslow delayed-rectifier K(+)-currenttroponin-Iultra-rapid delayed-rectifier K(+)-currentβ-ARβ-adrenoceptor

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