Related Experiment Video
Updated: May 7, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
No association between brain-derived neurotrophic factor G196A polymorphism and clinical features of Parkinson's
Marina Svetel1, Tatjana Pekmezovic, Vladana Markovic
1Clinic of Neurology CCS, University of Belgrade, Belgrade, Serbia.
Aims:
To investigate association of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene with clinical features in Serbian patients with Parkinson's disease (PD).
Methods:
The study comprised 177 consecutive PD patients. A comprehensive set of clinical scales was applied in all patients. The controls (n=366) were recruited among students. Single nucleotide polymorphisms (SNPs; rs6265) were analyzed using TaqMan assays.
Results:
PD patients (118 males) were aged 58.9±10.9 years, with a mean age at onset of 49.0±11.2 years. PD patients and controls had a similar distribution of genotypes and allele frequencies. The presence of the Met allele did not influence the clinical characteristics of PD patients (age at onset, family history, gender, disease duration, form of the disease, initial symptoms, cognitive abilities, depression, anxiety, disease severity, severity of motor and prevalence of nonmotor symptoms, and development of motor complications).
Conclusion:
Overall, the Val66Met polymorphism did not modify the clinical features in PD patients.
Related Concept Videos
Parkinson Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Neural Regulation
Parkinson's Disease: Overview
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

