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Updated: May 7, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
Molecular genetics of breast and ovarian cancer: recent advances and clinical implications
1Clinic of Radiation Oncology, Hannover Medical School, Hannover, Germany ; Clinic of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Abstract:
Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy.
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