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Cushing's syndrome in pregnancy
J Pickard1, A L Jochen, C N Sadur
1Department of Medicine, Denver General Hospital, Colorado.
Obstetrical & Gynecological Survey
|February 1, 1990
Summary
Cushing
Area of Science:
- Reproductive Endocrinology
- Endocrinology
- Obstetrics & Gynecology
Background:
- Cushing's syndrome significantly impacts female reproductive health, often causing infertility and pregnancy complications.
- Pregnancy in women with Cushing's syndrome is rare due to hormonal imbalances.
Observation:
- A review of 53 reported cases highlights the challenges of pregnancy with Cushing's syndrome.
- Adrenal tumors, including adenoma and carcinoma, are frequently implicated in pregnancy cases.
Findings:
- Cushing's syndrome during pregnancy is associated with increased risks of fetal wastage and prematurity.
- Glucocorticoid excess creates a catabolic maternal state detrimental to fetal development.
- Congenital malformations are not more common than in typical pregnancies.
Implications:
- Effective management of Cushing's syndrome is crucial for improving pregnancy outcomes.
- Further research is needed to understand the complex interplay between Cushing's syndrome and pregnancy.
- This condition underscores the importance of endocrine evaluation in pregnant patients with relevant symptoms.
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