Related Experiment Video
Updated: May 7, 2026
07:23
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
HypoxamiR regulation and function in ischemic cardiovascular diseases.
Simona Greco1, Carlo Gaetano, Fabio Martelli
11 Molecular Cardiology Laboratory , IRCCS-Policlinico San Donato, Milan, Italy .
Antioxidants & Redox Signaling
|September 24, 2013
Summary
Hypoxia-induced microRNAs (hypoxamiRs) are crucial regulators in cardiovascular diseases. Further understanding their roles can lead to new therapeutic strategies for conditions like heart attack and stroke.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Gene Regulation
Background:
- Hypoxia is a key factor in ischemic cardiovascular diseases.
- Hypoxia regulates specific microRNAs (miRNAs) known as hypoxia-induced miRNAs (hypoxamiRs).
- HypoxamiRs are vital in cellular responses to low oxygen, with miR-210 being prominent in ischemic conditions.
Purpose of the Study:
- To explore the role of hypoxamiRs in cardiovascular disease pathogenesis.
- To highlight the significance of hypoxamiRs in cellular responses to hypoxia.
- To underscore the need for deeper insights into hypoxamiR regulation and function.
Main Methods:
- Review of existing literature on hypoxamiRs and cardiovascular diseases.
- Analysis of the regulatory mechanisms of hypoxamiRs.
- Examination of the functional roles of hypoxamiRs in various cardiovascular pathologies.
Main Results:
- MicroRNAs (miRNAs) are deregulated in cardiovascular diseases such as myocardial infarction, hypertension, and stroke.
- HypoxamiRs, including miR-210, are induced by hypoxia and play a role in cardiovascular disease.
- Despite rapid knowledge growth, detailed understanding of hypoxamiR mechanisms is still required.
Conclusions:
- Understanding hypoxamiR function in cardiovascular disease gene networks is essential.
- This knowledge can reveal novel disease mechanisms.
- It may also guide the development of innovative therapeutic approaches for cardiovascular conditions.
Related Concept Videos
01:23Hypoxia
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
01:17Ischemic Heart Disease: Overview
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
01:27Regulation of the Cardiovascular System
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:29Pathophysiology of Cardiac Performance
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
01:23Physiological Control of Respiration
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...