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Updated: May 7, 2026
11:42
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating
Timur R Samatov1, Alexander G Tonevitsky, Udo Schumacher
1SRC Bioclinicum, Ugreshskaya str 2/85, Moscow 115088, Russia. t.samatov@bioclinicum.com.
Molecular Cancer
|September 24, 2013
Summary
Epithelial-mesenchymal transition (EMT) is crucial for development and cancer metastasis. This review explores EMT regulation and potential therapeutic targets for cancer treatment.
Area of Science:
- Cell Biology
- Molecular Biology
- Oncology
Background:
- Epithelial-mesenchymal transition (EMT) is a fundamental biological process.
- EMT plays a critical role in embryonic development and cancer progression, particularly in metastasis.
- Understanding EMT mechanisms is vital for developing effective cancer therapies.
Purpose of the Study:
- To review the transcriptional regulation of EMT.
- To explore the role of non-coding RNAs and alternative splicing in EMT.
- To summarize druggable targets for modulating EMT in cancer therapy.
Main Methods:
- Literature review of key regulatory mechanisms in EMT.
- Analysis of non-coding RNA involvement in EMT.
- Identification of cell adhesion molecules implicated in EMT.
- Survey of small molecules targeting EMT pathways.
Main Results:
- EMT is regulated by complex transcriptional networks.
- Non-coding RNAs and alternative splicing significantly influence EMT.
- Cell adhesion molecule dynamics are altered during EMT.
- Several small molecules show potential for modulating EMT.
Conclusions:
- EMT is a multifaceted process with diverse regulatory layers.
- Targeting EMT pathways offers a promising strategy for cancer treatment.
- Further research into druggable EMT modulators is warranted.
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