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Published on: January 22, 2013
Evaluation of ABO blood group as a prognostic marker in renal cell carcinoma (RCC)
Michela de Martino1, Matthias Waldert, Andrea Haitel
1Department of Urology, Medical University of Vienna, Vienna, Austria.
Objective:
To evaluate ABO blood group as a prognostic marker in patients with renal cell carcinoma (RCC).
Patients And Methods:
This retrospective study included 556 consecutive patients who underwent surgery for RCC at a single institution. The associations of ABO blood group with clinical and pathological variables were assessed using Kruskal-Wallis and chi-squared tests. The impact on overall survival (OS) and RCC-specific survival (RCC-SS) was analysed using univariable and multivariable Cox proportional hazards regression models.
Results:
Blood group O was associated with the absence of lymph node metastases (P = 0.034) and the presence of bilateral RCC (P = 0.017). No associations with age, gender, body mass index, Charlson comorbidity index, T stage, M stage, grade and histological subtype were observed. In univariable and multivariable survival analysis, ABO blood group was not associated with OS and RCC-SS.
Conclusions:
In the present study, ABO blood group was not linked with RCC prognosis. Blood group O may be associated with the absence of lymph node metastases and the presence of bilateral RCC. External validation in larger cohorts is necessary.
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