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Dense deposit disease: a 29-years electron microscopy experience.
Elham Ibrahim Seif1, Eman Abdalssalam Ibrahim, Nadia Galal Elhefnawy
1Electron microscopy unit, Department of Pathology, Ain Shams University Specialized Hospital (ASUSH), Cairo, Egypt.
Arab Journal of Nephrology and Transplantation
|September 24, 2013
Summary
Dense Deposit Disease (DDD) is a rare kidney disease. This study found DDD in 1% of biopsies, with distinct features in children versus adults, impacting diagnosis and prognosis.
Area of Science:
- Nephrology
- Pathology
- Electron Microscopy
Background:
- Dense Deposit Disease (DDD) is a severe renal condition with a high rate of progression to renal failure.
- Understanding the prevalence and pathological characteristics of DDD is crucial for patient management.
Purpose of the Study:
- To evaluate the prevalence and pathological features of Dense Deposit Disease (DDD) over a 29-year period.
- To compare the clinical and pathological differences of DDD between pediatric and adult patients.
Main Methods:
- Retrospective review of renal biopsies diagnosed with DDD at Ain Shams University between 1983 and 2011.
- Analysis of clinical presentations, light microscopy, immunohistochemistry (C3 staining), and electron microscopy findings.
- Comparison of features between pediatric and adult DDD cases.
Main Results:
- DDD represented 1% of 3283 renal biopsies, with 33 cases diagnosed.
- Nephrotic syndrome was the primary clinical presentation (51.5%), more frequent in children (80%) than adults (43%).
- Distinct pathological differences observed: glomerular damage more prominent in children (crescents 70%), while tubulointerstitial lesions (fibrosis 78.3%) were more common in adults.
Conclusions:
- Dense Deposit Disease (DDD) is a rare entity in Egypt, accounting for 1% of renal biopsies.
- Significant differences in pathological manifestations exist between pediatric and adult DDD patients.
- Children predominantly exhibit glomerular damage, whereas adults more frequently present with tubulointerstitial lesions, influencing disease course and treatment strategies.
