Screening for trace explosives by AccuTOF™-DART®: an in-depth validation study

Area of Science:

• Forensic Science
• Analytical Chemistry
• Mass Spectrometry

Background:

• Ambient ionization mass spectrometry is increasingly utilized for rapid sample analysis across various scientific fields.
• Direct Analysis in Real Time Mass Spectrometry (DART-MS) is a specific ambient ionization technique with potential applications in forensic analysis.
• Forensic samples such as drugs, explosives, inks, and bank dyes can be analyzed using ambient ionization methods.

Purpose of the Study:

• To evaluate the viability of Direct Analysis in Real Time Mass Spectrometry (DART-MS) as a screening tool for trace explosives.
• To conduct a validation study focusing on the analysis of trace amounts of nitro and peroxide-based explosives using DART-MS.

Main Methods:

• Method optimization for DART-MS analysis of explosives.
• Assessment of reproducibility and sensitivity for trace explosives detection.
• Development of a DART-MS search library for explosives identification.
• Evaluation of DART-MS for discriminating mixtures and blind sampling.

Main Results:

• DART-MS was validated as a screening tool for trace explosives, including nitro and peroxide-based compounds.
• The study addressed method optimization, reproducibility, and sensitivity parameters for explosives analysis.
• A search library was developed, and the technique's ability to discriminate mixtures and perform blind sampling was assessed.

Conclusions:

• Direct Analysis in Real Time Mass Spectrometry (DART-MS) is a promising technique for rapid, on-site screening of trace explosives.
• The study provides a comprehensive validation of DART-MS for forensic applications involving explosives detection.
• Further discussion includes the advantages and disadvantages of DART-MS compared to alternative screening methods.