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DRESS syndrome in a child treated for toxoplasma retinochoroiditis

Imran H Yusuf1, Prashant Sahare, G Darius Hildebrand

  • 1Royal Berkshire Hospital NHS Foundation Trust, London Road, Reading, United Kingdom.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|September 24, 2013
PubMed

Insights

Severe adverse drug reactions, including the life-threatening Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, can occur in children treated for toxoplasma retinochoroiditis. Early recognition and treatment are crucial for recovery.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Pharmacology

Background:

  • Toxoplasma retinochoroiditis requires treatment, often with a combination of sulfadiazine, pyrimethamine, folinic acid, and steroids.
  • Severe adverse drug reactions, such as DRESS syndrome, are known complications.
  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome has a significant mortality rate.

Observation:

  • A pediatric case of DRESS syndrome is presented in a child receiving standard treatment for toxoplasma retinochoroiditis.
  • The patient was treated with oral sulfadiazine, pyrimethamine, folinic acid, and steroids.
  • The child developed symptoms indicative of DRESS syndrome.

Findings:

  • Early clinical recognition of DRESS syndrome was achieved.
  • Prompt and appropriate treatment was initiated.
  • The child experienced a complete recovery without long-term sequelae.

Implications:

  • This case highlights the importance of recognizing DRESS syndrome in children treated for toxoplasma retinochoroiditis.
  • Counseling parents on potential nonspecific illness symptoms during sulfadiazine treatment is vital.
  • Vigilance for severe adverse drug reactions can lead to favorable outcomes in pediatric patients.

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