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Pseudokiller, qu'est-ce que c'est?

Douglas R Green1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38139, USA.

Immunity
|September 24, 2013
PubMed

Insights

Necroptosis, a regulated form of cell death, is executed by RIP kinases and MLKL. Murphy et al. demonstrate that this cell death pathway functions at the final execution stage.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Necroptosis is a programmed form of necrosis.
  • It is implicated in various physiological and pathological processes.
  • The molecular mechanisms are under intense investigation.

Purpose of the Study:

  • To elucidate the precise role of MLKL in necroptosis execution.
  • To determine the stage at which necroptosis operates within cell death pathways.

Main Methods:

  • Utilized genetic and biochemical approaches.
  • Investigated the function of key necroptosis mediators.

Main Results:

  • Demonstrated that MLKL is a critical downstream effector of RIP kinases in necroptosis.
  • Showed that necroptosis operates at or near the final execution step of cell death.

Conclusions:

  • MLKL is essential for the execution of necroptosis.
  • Necroptosis is a late-acting cell death program.

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