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Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Immunity
|September 24, 2013
Abstract:
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity.
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