Related Experiment Video

Updated: May 7, 2026

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses
14:05

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses

Published on: January 23, 2017

Wheeze phenotypes in young children have different courses during the preschool period

Jocelyne Just1, Philippe Saint-Pierre, Rahele Gouvis-Echraghi

  • 1Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand-Trousseau, Université Pierre et Marie Curie, Paris, France.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|September 24, 2013
PubMed

Insights

Predicting childhood asthma is challenging. New phenotypes like mild early viral wheeze (EVW) show better remission rates than atopic multiple-trigger wheeze (MTW) in preschoolers.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Childhood Asthma Research

Background:

  • Predictive models for childhood asthma in wheezy infants lack specificity.
  • Identifying distinct wheezing phenotypes is crucial for understanding disease trajectories.

Purpose of the Study:

  • To investigate if novel asthma phenotypes—mild early viral wheeze (EVW), atopic multiple-trigger wheeze (MTW), and nonatopic uncontrolled wheeze (NAUW)—exhibit different clinical courses during the preschool years.
  • To assess the preschool period wheezing trajectories of identified infant asthma phenotypes.

Main Methods:

  • A prospective cohort of wheezy infants (Trousseau Asthma Program) was phenotyped using cluster analysis based on 12 parameters.
  • Phenotypes were further assessed at 5 years of age by comparing initial classifications with subsequent wheezing trajectories.

Main Results:

  • Four distinct clusters emerged at age 5: asymptomatic, mild EVW, atopic MTW, and atopic severe uncontrolled wheeze (UW).
  • Mild EVW cases often resolved or remained mild; atopic MTW persisted; and NAUW frequently progressed to severe UW.
  • Remission was most common in mild EVW, while atopic MTW showed no remission.

Conclusions:

  • The identified phenotypes, particularly mild EVW and atopic MTW, demonstrate distinct and predictable preschool wheezing trajectories.
  • Mild EVW is associated with a higher likelihood of remission, whereas atopic MTW indicates a persistent disease course.
Abstract

More Related Videos

Quantifying Learning in Young Infants: Tracking Leg Actions During a Discovery-learning Task11:18

Quantifying Learning in Young Infants: Tracking Leg Actions During a Discovery-learning Task

Published on: June 1, 2015

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Language Development01:22

Language Development

Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Information Processing Approach01:30

Information Processing Approach

The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is also...