Pathogenesis of human hemangiosarcomas and hemangiomas
Liping Liu1, Satoko Kakiuchi-Kiyota, Lora L Arnold
1Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.
Human Pathology
|September 24, 2013
Summary
Human hemangiosarcomas may arise from early hematopoietic stem cells or endothelial progenitor cells (EPCs), unlike hemangiomas which originate from later-stage EPCs or differentiated endothelial cells.
Area of Science:
- Oncology
- Vascular Biology
- Stem Cell Research
Background:
- Hemangiosarcomas are aggressive vascular tumors with unclear human relevance despite chemical induction in mice.
- Understanding the cellular origins of these tumors is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the cellular origins of human hemangiosarcomas and hemangiomas.
- To compare the expression of hematopoietic and endothelial cell markers in these vascular tumors.
Main Methods:
- Immunohistochemistry was used to analyze marker expression in human hemangiosarcoma (n=12) and hemangioma (n=10) tissues.
- Evaluated markers included CD117, CD133, CD34, CD45, VEGFR2, CD31, Factor VIII-related antigen, and CD14.
Main Results:
- Hemangiosarcomas showed CD117 and CD45 expression, unlike hemangiomas.
- Both tumor types expressed CD34, VEGFR2, and Factor VIII-related antigen, with hemangiomas showing higher intensity for CD34 and Factor VIII.
- CD31 was positive in all hemangiosarcomas but only half of hemangiomas; CD133 and CD14 were largely negative.
Conclusions:
- Hemangiosarcomas likely originate from early endothelial progenitor cells (EPCs) or hematopoietic stem cells expressing CD117, CD34, and CD45.
- Hemangiomas appear to arise from later-stage EPCs or differentiated endothelial cells lacking most hematopoietic markers.
- This contrasts with mouse models where both tumor types may originate from early EPCs.
Keywords:
ECEPCEndothelial progenitor cellsH&EHemangiomaHemangiosarcomaHematopoietic stem cellsImmunohistochemistryPPARRTUUEA-1Ulex europaeus agglutinin-1VEGFR2endothelial cellendothelial progenitor cellhematoxylin and eosinperoxisome proliferator–activated receptorready to usevWFvascular endothelial growth factor receptor 2von Willebrand factor
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