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[Nutritional abnormalities in chronic obstructive pulmonary disease].

Joaquim Gea¹, Juana Martínez-Llorens¹, Esther Barreiro¹

¹Servicio de Neumología, Hospital del Mar-IMIM, Barcelona, España; Departamento de Ciencias Experimentales y de la Salud (CEXS), Universitat Pompeu Fabra, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Bunyola, Mallorca, España.

Medicina Clinica

|September 24, 2013

Summary

Nutritional abnormalities are common in chronic obstructive pulmonary disease (COPD), leading to muscle dysfunction and exercise limitation. Therapeutic strategies include lifestyle changes, nutritional support, and potentially anabolic drugs.

Keywords:

Anabolic drugs Anabolizantes Bajo peso Chronic obstruction pulmonary disease Disfunción muscular Ejercicio Enfermedad pulmonar obstructiva crónica Exercise Lean mass Low weight Masa magra Muscle dysfunction Nutrición Nutrition

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Area of Science:

Pulmonary Medicine
Nutritional Science
Biochemistry

Context:

Nutritional abnormalities affect 2-50% of patients with chronic obstructive pulmonary disease (COPD).
Diagnosis involves anthropometry, bioelectrical impedance, and body/lean mass indices.
Contributing factors include caloric imbalance, hormonal disruption, inflammation, and aging.

Purpose:

To review the diagnostic tools, consequences, underlying mechanisms, and therapeutic strategies for nutritional abnormalities in COPD.

Summary:

Muscle dysfunction and exercise limitation are key consequences of COPD-related malnutrition.
The primary molecular mechanism involves an imbalance between protein synthesis and breakdown.
Therapeutic approaches encompass lifestyle modifications, nutritional support, and novel anabolic drug therapies.

Impact:

Understanding these factors can guide interventions to improve patient outcomes and quality of life in COPD.
Highlights the potential of anabolic drugs as a new therapeutic avenue for managing malnutrition in COPD patients.