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Updated: May 7, 2026
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
Published on: October 25, 2024
Association of blood type and patient characteristics with ovarian reserve
Kathryn S Timberlake1, Kristie L Foley, Bradley S Hurst
1Wake Forest School of Medicine, Winston-Salem, North Carolina.
Objective:
To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age.
Design:
Cross-sectional study.
Setting:
Academic medical center, Division of Reproductive Endocrinology and Infertility.
Patient(S):
Women undergoing in vitro fertilization (IVF) from 2006-2011 (n = 305).
Intervention(S):
None.
Main Outcome Measure(S):
Presence of DOR in relation to a patient's blood type.
Result(S):
Other investigators have reported an increased risk for DOR in patients with blood type O and a protective effect on ovarian reserve for blood type A. We observed no association between a woman's blood type and DOR. We found an increased risk for DOR in patients aged 35 and older. Obesity (BMI ≥ 30 vs. BMI <25) was associated with lower odds of DOR.
Conclusion(S):
In comparison with blood type A, blood type O is not associated with an increase in DOR. We found no clinical implications for using blood type as a risk factor for DOR.
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