[Consensus document: recommendations for the use of equations to estimate glomerular filtration rate in children]

Area of Science:

• Pediatric Nephrology
• Clinical Biochemistry
• Renal Function Assessment

Background:

• The 2002 K/DOQI guidelines revolutionized chronic kidney disease (CKD) assessment by emphasizing estimated glomerular filtration rate (eGFR) alongside serum creatinine.
• Despite updated guidelines, the clinical laboratory reporting of eGFR in pediatric populations remains significantly underutilized.
• Growing research highlights the importance of CKD screening, novel eGFR equations, and advancements in creatinine and cystatin C measurement methods.

Framework:

• This document provides evidence-based recommendations for evaluating renal function and utilizing eGFR equations in children aged 0-18 years.
• It addresses the need for standardized approaches to pediatric GFR estimation, considering recent scientific advancements.
• The framework aims to bridge the gap between clinical guidelines and laboratory practice in pediatric nephrology.

Implementation:

• Collaboration between pediatrics and clinical laboratories is crucial for implementing updated GFR estimation practices.
• Recommendations focus on the practical application of validated eGFR equations in routine pediatric care.
• The goal is to improve the consistent and accurate reporting of renal function in children.

Implications:

• Adoption of these recommendations will enhance the early detection and management of kidney disease in children.
• Standardized eGFR reporting will improve the accuracy of pediatric renal function assessment and patient monitoring.
• This initiative aims to optimize clinical decision-making and patient outcomes in pediatric nephrology.