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Updated: May 7, 2026

Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
Published on: February 8, 2022
Location and cellular stages of natural killer cell development
Jianhua Yu1, Aharon G Freud, Michael A Caligiuri
1Division of Hematology, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA; Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA.
Abstract:
The identification of distinct tissue-specific natural killer (NK) cell populations that apparently mature from local precursor populations has brought new insight into the diversity and developmental regulation of this important lymphoid subset. NK cells provide a necessary link between the early (innate) and late (adaptive) immune responses to infection. Gaining a better understanding of the processes that govern NK cell development should allow us to harness better NK cell functions in multiple clinical settings, as well as to gain further insight into how these cells undergo malignant transformation. In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice.
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