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Updated: May 7, 2026

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
Published on: August 17, 2016
Influence of metal ions on the ⁶⁸Ga-labeling of DOTATATE
Elisabeth Oehlke1, Van So Le, Nigel Lengkeek
1Life Sciences Division, Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, New South Wales, Australia.
Abstract:
The influence of metal cations (Fe³⁺, Fe²⁺, In³⁺, Cu²⁺, Ca²⁺, Al³⁺, Co²⁺, Lu³⁺, Ni²⁺, Pb²⁺, Ti⁴⁺, Y³⁺, Yb³⁺, Zn²⁺, and Zr⁴⁺) on the radiolabeling yield of [⁶⁸Ga(DOTATATE)] was evaluated. Our most important observation was that, within our experimental limit, the metal ion/ligand ratio plays a critical role on the influence of most metal ions. More in-depth studies, with Cu²⁺ and Fe³⁺, revealed that reaction temperature and concentration changes have little effect, but speciation changes with pH are crucial. Furthermore, we found that [⁶⁸Ga(DOTATATE)] is stable in the presence of high concentrations of Fe³⁺, Zn²⁺ and Pb²⁺, but transmetalates with Cu²⁺ at 95°C.
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