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Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation
Lei He1, Xuesong Wang, Cong Zhao
1Department of Chemistry, Renmin University of China, Beijing, 100872, China. whdu@chem.ruc.edu.cn.
Metallomics : Integrated Biometal Science
|September 24, 2013
Abstract:
Human islet amyloid polypeptide (hIAPP) can be linked to the pathology of type II diabetes. In this study, aromatic ring-containing Ru complexes were found to effectively inhibit the fibril formation of hIAPP and promote the disaggregation of formed fibrils by remarkably changing the β-sheet components.
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