Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using Data to Drive Policy Action: An Urgent Call for Funding Interdisciplinary Team-Based Rheumatology Care.

Healthcare quarterly (Toronto, Ont.)·2026
Same author

Does pain pattern matter? Association of intermittent, constant, predictable and unpredictable knee pain to patient-reported knee symptom acceptability in knee osteoarthritis.

Osteoarthritis and cartilage open·2026
Same author

Risk stratification improves outcomes in an osteoporosis fracture liaison service.

Archives of osteoporosis·2026
Same author

OA fundamentals series: Diagnosis and clinical assessment of osteoarthritis.

Osteoarthritis and cartilage·2026
Same author

Parity, body mass index, smoking and risk of rheumatoid arthritis: data from the Australian Longitudinal Study on Women's Health.

BMC rheumatology·2026
Same author

Blueprints for Change: Integrating Systems Thinking into Musculoskeletal Health Policy; A Response to Recent Commentaries.

International journal of health policy and management·2026
Same journal

Interpreting maternal and neonatal outcomes in COVID-19-affected pregnancies.

The Indian journal of medical research·2026
Same journal

Incorporating patient- and caregiver-derived needs into national cancer research priority setting in India.

The Indian journal of medical research·2026
Same journal

Advances in glioblastoma: Is there light at the end of the tunnel?

The Indian journal of medical research·2026
Same journal

Authors' response.

The Indian journal of medical research·2026
Same journal

Formulation and sensory evaluation of nutrient-dense complementary food mixes for infants and young children aligned with national nutritional standards in India: A D-optimal mixture design approach.

The Indian journal of medical research·2026
Same journal

Prevalence of hypothyroidism among pregnant women and associated feto-maternal outcomes in India: Systematic review and meta-analysis.

The Indian journal of medical research·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Obesity & osteoarthritis.

Lauren K King1, Lyn March, Ananthila Anandacoomarasamy

  • 1Department of Rheumatology, Concord Hospital, Sydney; The University of Sydney, Australia.

The Indian Journal of Medical Research
|September 24, 2013
PubMed
Summary
This summary is machine-generated.

Obesity significantly impacts the musculoskeletal system, increasing osteoarthritis (OA) risk and severity. Weight loss in OA patients can improve pain and slow joint damage progression.

More Related Videos

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Related Experiment Videos

Last Updated: May 7, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Area of Science:

  • Orthopedics
  • Rheumatology
  • Metabolic disease

Background:

  • Obesity is a major risk factor for osteoarthritis (OA), a degenerative joint disease.
  • OA causes pain, reduced mobility, and diminished quality of life.
  • Obesity's impact on OA involves mechanical joint stress and metabolic factors.

Purpose of the Study:

  • To review the significant impact of obesity on the musculoskeletal system, particularly osteoarthritis.
  • To explore the relationship between obesity, OA incidence, progression, and joint replacement rates.
  • To highlight the benefits of weight loss for OA management.

Main Methods:

  • Literature review and synthesis of existing research on obesity and osteoarthritis.
  • Analysis of biomechanical, hormonal, and cytokine dysregulation in OA pathogenesis.
  • Evaluation of the effects of weight loss on OA symptoms and structural damage.

Main Results:

  • Obesity is linked to OA development and worsening in both weight-bearing and non-weight-bearing joints.
  • Obesity increases the likelihood of joint replacements and surgical complications.
  • Weight loss demonstrates significant improvements in OA pain and delays structural joint damage.

Conclusions:

  • Obesity poses a substantial threat to musculoskeletal health, primarily through osteoarthritis.
  • Weight reduction is a crucial intervention for managing OA, improving patient outcomes.
  • Further research is needed to differentiate the mechanical and metabolic roles in OA pathogenesis.