Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional and morphological stasis during molecular evolution.

R C Williams1

  • 1Department of Anthropology, Arizona State University, Tempe 85287-2402.

American Journal of Physical Anthropology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Studies of antibody to herpes simplex virus Fc gamma-binding protein gE in patients with rheumatoid arthritis, juvenile rheumatoid arthritis and normal controls.

Scandinavian journal of immunology·1992
Same author

Radiographic evaluation of crestal bone levels adjacent to nonsubmerged titanium implants.

Clinical oral implants research·1992
Same author

Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix.

Journal of immunology (Baltimore, Md. : 1950)·1992
Same author

Human anti-F(ab')2 antibodies show preferential reactivity for F(ab')2 molecules bearing lambda light chains.

Clinical immunology and immunopathology·1992
Same author

Differential mapping of Fc gamma-binding and monoclonal antibody-reactive epitopes on gE, the Fc gamma-binding glycoprotein of herpes simplex virus type 1.

Journal of immunology (Baltimore, Md. : 1950)·1992
Same author

Heteroclitic polyclonal and monoclonal anti-Gm(a) and anti-Gm(g) human rheumatoid factors react with epitopes induced in Gm(a-), Gm(g-) IgG by interaction with antigen or by nonspecific aggregation. A possible mechanism for the in vivo generation of rheumatoid factors.

Journal of immunology (Baltimore, Md. : 1950)·1992
Same journal

A geometric morphometric assessment of shape variation in adult pelvic morphology.

American journal of physical anthropology·2021
Same journal

Corrigendum: Infanticide in chimpanzees: Taphonomic case studies from Gombe.

American journal of physical anthropology·2021
Same journal

Sexual dimorphism in the size and shape of the non-obstetric pelvis across anthropoids.

American journal of physical anthropology·2021
Same journal

The biological index of frailty: A new index for the assessment of frailty in human skeletal remains.

American journal of physical anthropology·2021
Same journal

Mass violence in Copper Age Europe: The massacre burial site from Potočani, Croatia.

American journal of physical anthropology·2021
Same journal

Skeletal evidence of structural violence among undocumented migrants from Mexico and Central America.

American journal of physical anthropology·2021
See all related articles

Molecular evolution has significantly impacted beta 2-microglobulin, yet murine beta 2-microglobulin still influences human cell antigens. Human and equine alpha-globin show minimal structural divergence.

Area of Science:

  • Molecular Evolution
  • Biochemistry
  • Immunogenetics

Background:

  • Estimating evolutionary distances between proteins is crucial for understanding molecular evolution.
  • Human beta 2-microglobulin and alpha-globin serve as models for studying protein evolution.
  • Kimura's theory of neutral allelic drift provides a framework for interpreting molecular evolution.

Purpose of the Study:

  • To estimate the evolutionary distance between human and murine beta 2-microglobulin.
  • To compare the evolutionary distance between human and equine alpha-globin.
  • To investigate the functional and structural conservation of these proteins despite evolutionary divergence.

Main Methods:

  • Utilized molecular evolutionary techniques from Miyata and Yasunaga (1980) and Kimura (1980).

Related Experiment Videos

  • Compared human beta 2-microglobulin with its murine homolog.
  • Analyzed human and equine alpha-globin sequences.

    • Main Results:

    • Significant molecular evolution observed in beta 2-microglobulin since divergence from a common ancestor.
    • Kimura's evolutionary distance (K) for beta 2-microglobulin: 0.353; Miyata and Yasunaga (KS, KA): 0.708, 0.171.
    • Lower evolutionary distance for human and equine alpha-globin (K: 0.152; KS, KA: 0.293, 0.084).
    • Murine beta 2-microglobulin functionally expressed HLA class I antigens on human-mouse hybrid cells.
    • Human and equine deoxyhemoglobin exhibit nearly identical tertiary structures.

    Conclusions:

    • Despite substantial molecular evolution, beta 2-microglobulin retains functional capacity across species.
    • Conserved tertiary structure in deoxyhemoglobin suggests functional constraints.
    • Findings support Kimura's neutral theory of molecular evolution, indicating a role for neutral drift alongside potential functional selection.