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Related Concept Videos

Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

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Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
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Published on: September 19, 2025

Mood disturbance after infection.

Pramudie Gunaratne1, Andrew R Lloyd, Ute Vollmer-Conna

  • 11Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Sydney, Australia.

The Australian and New Zealand Journal of Psychiatry
|September 24, 2013
PubMed
Summary

Acute infections may trigger major depression in vulnerable individuals due to complex interactions. Understanding these links is crucial for developing effective prevention and treatment strategies for depression.

Keywords:
Post-infective mood disturbanceacute infectionacute sickness responsedepressionfatiguemood disorder

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • A hypothesized link exists between acute infections and major depression.
  • Contemporary literature increasingly recognizes this connection, prompting further investigation.

Purpose of the Study:

  • To review evidence linking acute, self-limiting infections with major depression.
  • To summarize the pathophysiological mechanisms underlying this association.

Main Methods:

  • Comprehensive literature search of Embase, MEDLINE, PsycINFO, and PubMed.
  • Inclusion of articles from retrieved paper bibliographies.

Main Results:

  • Retrospective and prospective studies confirm an association between infection and subsequent mood disturbance.
  • Evidence suggests a multifactorial vulnerability to major depression following acute infection.
  • Genetic, neuroendocrine, autonomic, and psychosocial factors interact to influence depressive response.

Conclusions:

  • Mood disturbance during infection may be a host-protective response.
  • In vulnerable individuals, this response can develop into sustained major depression.
  • Further research is needed to identify predisposing and perpetuating factors for depression in infection.