Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino
Veera V E Ramesh1, Kuruppanthara N Vijayadas, Snehal Dhokale
1Division of Organic Synthesis, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India. gj.sanjayan@ncl.res.in.
Abstract:
This communication describes the folding propensity of a heterofoldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1:2:1 (α:β:α) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio of the amino acid residues.
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