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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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The influence of gastroschisis on plasmatic coagulation, humoral immunity, and C-reactive protein

H G Limbach1, A Quinten, H J Jesberger

  • 1Universitätsklinik für Kinder-und Jugendmedizin, Frühgeborenenund Intensivstation, D-66421, Homburg/Saar, Germany.

Pediatric Surgery International
|September 24, 2013
PubMed

Insights

Gastroschisis (GS) in premature infants causes inflammation, leading to blood clotting issues (hypercoagulability) and low antibody levels (hypogammaglobulinemia). Prophylactic low-dose heparin is recommended to prevent serious complications.

Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Hematology

Background:

  • Gastroschisis (GS) is a congenital condition where intestines are exposed outside the body.
  • Infants with GS, especially premature ones, exhibit chronic inflammatory reactions on intestinal surfaces.
  • These reactions are linked to significant coagulation abnormalities and immune deficiencies.

Purpose of the Study:

  • To investigate coagulation profiles in infants with gastroschisis.
  • To compare these profiles with those of infants with omphalocele and healthy controls.
  • To identify potential risks and therapeutic strategies for gastroschisis-associated complications.

Main Methods:

  • Coagulation studies were performed on 12 infants with gastroschisis.
  • Comparative analysis included 4 infants with omphalocele, healthy premature infants, and term infants.
  • Assessment focused on fibrinogen levels, coagulation status, and immunoglobulin levels.

Main Results:

  • Gastroschisis patients exhibited severe hyperfibrinogenemia and hypercoagulability, particularly in premature infants.
  • Marked hypogammaglobulinemia was observed in GS patients, correlating with increased infection rates.
  • Coagulation abnormalities were significantly more pronounced in GS compared to omphalocele and control groups.

Conclusions:

  • Gastroschisis is associated with significant hypercoagulability and hypogammaglobulinemia, increasing risks.
  • Thromboembolic complications and disseminated intravascular coagulation are heightened risks.
  • Prophylactic low-dose heparin therapy is indicated for infants with gastroschisis.

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