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The relationship between estimated average glucose and fasting plasma glucose
Clinical Chemistry and Laboratory Medicine
|September 24, 2013
Summary
Fasting plasma glucose (FPG) moderately correlates with estimated average glucose (eAG), but this relationship weakens at lower FPG levels, especially in diabetics. Glycemic control influences the eAG and FPG connection.
Area of Science:
- Endocrinology
- Clinical Chemistry
- Diabetes Research
Background:
- Estimated average glucose (eAG) provides a measure of average glycemic status over months, derived from hemoglobin A1c (HbA1c).
- The International HbA1c-Derived Average Glucose (ADAG) Trial established a linear relationship between HbA1c and eAG in 2008.
- Understanding the correlation between fasting plasma glucose (FPG) and eAG is crucial for diabetes management.
Purpose of the Study:
- To investigate the relationship between fasting plasma glucose (FPG) and estimated average glucose (eAG).
- To determine if glycemic control affects the correlation between FPG and eAG.
Main Methods:
- A retrospective analysis of 6443 subjects (5567 diabetic, 876 non-diabetic) was performed.
- HbA1c and FPG levels were collected, and eAG was calculated using the ADAG trial regression equation.
- Subjects were stratified into subgroups based on FPG levels to assess correlation variations.
Main Results:
- A moderate correlation (r=0.672, p<0.001) was observed between FPG and eAG in all subjects.
- The correlation between FPG and eAG decreased significantly in both diabetic and non-diabetic subgroups as FPG levels lowered.
- Differences between eAG and FPG were statistically significant (p<0.001), with 81% of diabetic patients showing lower FPG than eAG.
Conclusions:
- The relationship between eAG and FPG is influenced by the level of glycemic control.
- These findings enhance the understanding of eAG and its relationship with FPG in diverse glycemic states.
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