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Updated: May 7, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

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Volume Measures Using a Digital Image Analysis System are Reliable in Diabetic Foot Ulcers.

Sue E Gardner¹, Rita A Frantz, Stephen L Hillis

¹University of Iowa College of Nursing, Iowa City, IA.

Wounds : a Compendium of Clinical Research and Practice

|September 24, 2013

Summary

This summary is machine-generated.

Digital imaging software VeVMD shows acceptable reliability for measuring diabetic foot ulcer (DFU) wound volume. This tool is valuable for wound healing research and clinical management, though further studies are needed for other wound types.

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High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

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Published on: March 16, 2022

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

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Published on: January 10, 2025

Area of Science:

Wound healing research
Medical imaging technology
Diabetic foot ulcer management

Background:

Accurate wound size measurement is crucial for effective wound healing research and clinical practice.
Digital imaging and photogrammetric software, like VeVMD, are increasingly used for estimating wound volume.
The reliability of VeVMD for wound volume assessment remained undetermined prior to this study.

Purpose of the Study:

To evaluate the reliability of wound volume measurements using VeVMD software.
To assess both inter-rater and intra-rater reliability of VeVMD in quantifying wound volume.

Main Methods:

A cross-sectional study involving adults with full-thickness, neuropathic diabetic foot ulcers (DFU) was conducted.
Ulcer images were captured and analyzed using VeVMD software to determine wound volume.
Four independent raters performed repeated measurements over two weeks, with blinding, to compute inter- and intra-rater correlations.

Main Results:

Analysis included 33 subjects with DFU. Initial inter-rater reliability was 0.745 and intra-rater reliability was 0.868.
Exclusion of four ulcers with complex recessed areas improved reliability significantly.
Post-exclusion, inter-rater reliability reached 0.970 and intra-rater reliability reached 0.981, indicating excellent agreement.

Conclusions:

VeVMD demonstrates acceptable reliability for measuring diabetic foot ulcer volumes, even with variations in margin definition.
The software's performance is reliable for DFU, supporting its use in research and clinical settings.
Further research is required to ascertain VeVMD's performance with wound types beyond DFU.