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Prognostic value of resting pulmonary function in heart failure.
Thomas P Olson1, Dustin L Denzer, William L Sinnett
1Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
|September 24, 2013
Summary
Resting pulmonary function measurements, including forced vital capacity and diffusing capacity, can predict mortality in heart failure patients. Lower lung function indicates a higher risk of death or transplant.
Area of Science:
- Cardiology
- Pulmonology
- Medical Prognostics
Background:
- Heart failure (HF) is closely linked to pulmonary system changes.
- Assessing resting pulmonary function (PF) offers potential prognostic insights in HF patients.
Purpose of the Study:
- To investigate the prognostic value of resting pulmonary function (PF) in patients with heart failure (HF).
Main Methods:
- 134 HF patients were analyzed, measuring forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), diffusing capacity of the lungs for carbon monoxide (DLCO), and alveolar volume (VA).
- Patients were stratified into tertiles based on PF measurements.
- Survival analysis was performed using log-rank Mantel-Cox tests with chi-square analysis and Bonferroni correction.
Main Results:
- Significant differences in survival were observed across tertiles for FVC (P < 0.001), FEV1 (P < 0.001), and DLCO (P = 0.003).
- Alveolar volume (VA) also showed significant differences between certain tertiles (P = 0.01).
- Lower predicted values for FVC, FEV1, and DLCO were associated with poorer survival outcomes.
Conclusions:
- Resting pulmonary function tests are valuable predictors of all-cause mortality in a defined heart failure cohort.
- These simple, non-invasive measures can aid in risk stratification for HF patients.
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