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Updated: May 7, 2026

Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
THERMODYNAMIC CHARACTERIZATION OF METAL PHTHALOCYANINES-HUMAN SERUM ALBUMIN INTERACTIONS
Cecil L Jones1, Chakeeta Jones, Lana Thomas
1Department of Natural Science & Mathematics, Chemistry Program, Savannah State University, Savannah, GA 31404.
Abstract:
The temperature dependence of the binding constants for human serum albumin and sulfonated metal-phthalocyanines were estimated by fluorescence spectroscopy. Stern-Volmer's analysis and Chipman's fits provided binding data for van't Hoff calculations of the thermodynamic parameters governing these interactions. Results show that the formations of the HSA- phthalocyanine complexes are favorable processes by both the ΔH° and ΔS°. However, the formation of HSA-AIPcS4 has a stronger dependence than HSA-ZnPcS 4on ΔS°.
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