Related Experiment Video
Updated: May 7, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure
Queen Henry-Okafor1, Sean P Collins, Cathy A Jenkins
1Department of Cardiovascular Medicine, Department of Emergency Medicine and the Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Objectives:
We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).
Methods:
We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.
Results:
Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.
Conclusion:
Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.
Related Concept Videos
Heart Failure IV: Classification and Diagnostic Evaluation
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Coronary Syndrome III: Diagnostic Studies
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Heart Failure VI: Adjunct Therapies