Related Experiment Video

Updated: May 7, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Non-high-density lipoprotein cholesterol on the risks of stroke: a result from the Kailuan study

Jianwei Wu1, Shengyun Chen, Yong Zhou

  • 1Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.

Plos One
|September 24, 2013
PubMed

Insights

Elevated non-high-density lipoprotein cholesterol (non-HDLC) is a significant risk factor for stroke. Higher non-HDLC levels increase the likelihood of total and ischemic stroke, but not hemorrhagic types.

Area of Science:

  • Cardiovascular Epidemiology
  • Lipid Metabolism
  • Cerebrovascular Disease

Background:

  • Non-high-density lipoprotein cholesterol (non-HDLC) is increasingly recognized as a key lipid marker.
  • Understanding the association between non-HDLC and stroke subtypes is crucial for risk stratification.

Purpose of the Study:

  • To prospectively investigate the relationship between serum non-HDLC levels and the incidence of stroke and its subtypes.
  • To determine if non-HDLC is an independent risk factor for different types of stroke.

Main Methods:

  • A cohort of 95,916 Chinese adults without prior cardiovascular events was followed for four years.
  • Serum non-HDLC was calculated by subtracting high-density lipoprotein cholesterol (HDLC) from total cholesterol.
  • Cox proportional hazards models were employed to assess the risk of stroke and its subtypes.

Main Results:

  • A total of 1614 stroke events were recorded, including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage.
  • Increased non-HDLC levels were associated with a higher risk of total stroke (HR 1.08 per 20 mg/dL) and ischemic stroke (HR 1.10 per 20 mg/dL).
  • The highest quintiles of non-HDLC showed significantly elevated risks for total and ischemic stroke after adjusting for confounders.

Conclusions:

  • Serum non-HDLC is an independent risk factor for both total and ischemic stroke.
  • Higher concentrations of non-HDLC are linked to increased risks of total and ischemic stroke.
  • Non-HDLC levels did not show a significant association with the risk of intracerebral or subarachnoid hemorrhage.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...