Everything in moderation: Proteolytic regulation of centrosome duplication

The presence of too many or too few centrosomes at mitosis can disrupt the timely formation of a bipolar spindle and may lead to aneuploidy and cancer. Strict control of centrosome duplication is therefore crucial. Centrosome duplication must occur once per cell cycle and the number of new centrioles made must be tightly controlled. The importance of protein degradation for the orderly progression of the cell cycle has long been recognized, but until recently the role of proteolysis in the regulation of centrosome duplication had not been appreciated. Recent evidence suggests that restricting protein levels so that a single new centriole is built next to each pre-existing centriole is one way in which centrosome duplication is controlled. Here we discuss our recent finding that the SCF ubiquitin ligase complex regulates centrosome duplication in C. elegans in the larger context of the proteolytic regulation of centrosome duplication.