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Influence of endothelin-1 and nitric oxide on left ventricular remodelling in patients on peritoneal dialysis
Damir Rebic1, Senija Rasic, Velma Rebic
1Clinic for Nephrology, Clinical Center of University of Sarajevo , Sarajevo , Bosnia and Herzegovina and.
Insights
Endothelin-1 (ET-1) and nitric oxide (NO) levels are linked to left ventricular remodeling in patients undergoing peritoneal dialysis (PD). Changes in ET-1 and NO correlate with improvements in left ventricular hypertrophy after PD treatment.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Left ventricular hypertrophy (LVH) is a common cardiac issue in chronic dialysis patients.
- The study investigates the role of endothelin-1 (ET-1) and nitric oxide (NO) in LV remodeling in peritoneal dialysis (PD) patients.
Purpose of the Study:
- To determine the association between ET-1, NO, and echocardiographic parameters in PD patients.
- To assess the participation of ET-1 and NO in left ventricular (LV) remodeling during PD treatment.
Main Methods:
- Prospective longitudinal study of 40 PD patients.
- Measured serum ET-1 and NO levels at baseline and 12 months, alongside echocardiography.
- Linear regression analysis identified independent predictors of LV mass index.
Main Results:
- Serum ET-1 decreased and NO increased significantly after 12 months of PD (p < 0.01).
- LVH was prevalent at baseline (72.5%), with significant reduction in LV mass index after treatment (p < 0.001).
- ET-1 and NO were independent predictors of LV mass index.
Conclusions:
- ET-1 and NO are independently associated with left ventricular remodeling in PD patients.
- These vasoactive substances play a crucial role in cardiac structural changes during PD therapy.
Background:
Left ventricular hypertrophy is the most common structural cardiac alteration in chronic dialysis patients. The aim of this study was to determine the possible association of endotelin-1 (ET-1) and nitric oxide (NO) with parameters of echocardiography in order to assess their participation in left ventricular (LV) remodeling in patients on peritoneal dialysis (PD).
Methods:
This prospective longitudinal study included 40 PD patients. Serum levels of ET-1 and NO baseline and after 12 months of PD treatment were measured and compared with echocardiography parameters done at the same time of PD treatment. Linear regression analysis was used to detect independent correlations of variables.
Results:
Mean ET-1 serum concentration decreased significantly after 12 months of PD treatment compared to baseline values (p < 0.01). NO serum concentration increased significantly 12 months after treatment compared to baseline values (p < 0.01). Left ventricular hypertrophy (LVH) was observed in 72.5% of patients at baseline with significant reduction in LV mass index after 12 months of PD treatment (p < 0.001). On linear regression analysis serum concentration of ET-1 was independent predictors of LV mass index, as well as NO at the end of observed period.
Conclusions:
According to our data ET-1 and NO are independently related to the process of left ventricular remodeling in PD patients.
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