Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study

M Merad, W Soufi, S Ghalem

  • 1Laboratory of Naturals Products and Bio actives-LASNABIO, University of Tlemcen, Algeria. s_ghalem2002@yahoo.fr.

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
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