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Updated: May 7, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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NMR structural studies of human cellular prion proteins

Ivana Biljan1, Gregor Ilc, Gabriele Giachin

  • 1Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia. janez.plavec@ki.si.

Current Topics in Medicinal Chemistry
|September 25, 2013
PubMed
Summary

Prion diseases involve misfolding of the cellular prion protein (PrP(C)) into a pathological form (PrP(Sc)). Structural studies of human PrP variants reveal subtle differences that may explain prion formation and disease development.

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