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Updated: May 7, 2026
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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Next generation biomarkers for brain injury
Laura D Serpero1, Valentina Bellissima, Micaela Colivicchi
1Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital , Alessandria , Italy .
Summary
Non-invasive biomarkers show promise for monitoring infant brain injury risk. Studies indicate these biochemical markers correlate with brain damage in newborns, aiding clinical assessment.
Area of Science:
- Perinatal Medicine
- Neonatal Neurology
- Biochemical Monitoring
Background:
- Infants at risk for brain injury require effective monitoring.
- Hypoxia triggers biochemical cascades leading to neonatal brain damage.
- Biomarkers in biological fluids may indicate short- and long-term brain damage.
Purpose of the Study:
- To review current non-invasive brain biochemical monitoring biomarkers in perinatal medicine.
- To assess the progress of these biomarkers against established institutional criteria.
Main Methods:
- Literature review of studies investigating biomarkers for neonatal brain injury.
- Analysis of biomarker concentrations in various biological fluids.
- Evaluation of biomarker data against USA and European institutional criteria.
Main Results:
- Several biomarkers (neuro-proteins, calcium-binding proteins, oxidative stress markers, etc.) have been investigated.
- Increased biomarker concentrations correlate with hypoxic brain injury in preterm and term neonates.
- Progress varies among biomarkers regarding fulfillment of institutional criteria for guideline inclusion.
Conclusions:
- Non-invasive biomarkers offer potential for monitoring neonatal brain injury.
- Further validation is needed to meet stringent criteria for clinical guideline adoption.
- Continued research is essential for advancing biochemical monitoring in perinatal medicine.
