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Related Experiment Video

Updated: May 7, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

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Published on: May 30, 2011

Quantification of Perfusion Changes during a Motor Task Using Arterial Spin Labeling.

P Vilela1, M Pimentel, I Sousa

  • 1Imaging Department, Hospital da Luz; Lisbon, Portugal - pvilela@hospitaldaluz.pt.

The Neuroradiology Journal
|September 25, 2013
PubMed
Summary
This summary is machine-generated.

Arterial spin labeling (ASL) MRI effectively measures brain blood flow changes during motor tasks. A block design ASL-BOLD protocol is recommended for its efficiency and ability to detect perfusion variations.

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Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Area of Science:

  • Neuroimaging
  • Physiology
  • Medical Physics

Background:

  • Arterial spin labeling (ASL) is a non-invasive MRI technique for quantitative perfusion measurement (regional cerebral blood flow, rCBF).
  • ASL utilizes the magnetic labeling of blood water spins to detect perfusion-weighted signals.
  • This method allows repeated quantification of brain perfusion variations in response to stimuli.

Purpose of the Study:

  • To evaluate regional cerebral blood flow (rCBF) variations induced by neural activity during a motor task using ASL.
  • To compare the efficacy of two functional ASL protocols: activation vs. rest and block design.
  • To determine the optimal ASL protocol for assessing perfusion changes related to endogenous stimuli.

Main Methods:

  • A Siemens Verio 3T MRI system with a 12-channel head coil and pulsed ASL Q2TIPS-PICORE sequence was used.
  • Two protocols were employed: #1 (rest/task scan, ~8 min) and #2 (block design, ~4 min).
  • Fifteen healthy volunteers performed a sequential thumb-digit opposition motor task; data was processed using FSL.

Main Results:

  • Both protocols detected consistent rCBF variations during motor task activation.
  • Protocol #1 yielded a relative perfusion change of 73±6%, while Protocol #2 showed 62±7%.
  • The block design protocol required shorter acquisition times and allowed simultaneous BOLD signal acquisition.

Conclusions:

  • Both activation vs. rest and block design ASL protocols can detect perfusion variations associated with motor tasks.
  • The block design ASL-BOLD protocol offers advantages in scan time and simultaneous BOLD acquisition.
  • A block design ASL-BOLD approach is suggested as a preferable method for evaluating perfusion changes due to endogenous stimuli.