Neurosarcoidosis: radiologic features in five patients

H Aburano1, M Hashimoto, Y Yoshie

  • 1Department of Radiology, Kanazawa University School of Medicine; Kanazawa, Japan - aburano@arrow.ocn.ne.jp.

The Neuroradiology Journal
|September 25, 2013
PubMed

Insights

Radiological features of neurosarcoidosis are highly variable, complicating diagnosis. Specific imaging findings, like pial spread and meningeal masses with characteristic T2/FLAIR signal changes, can suggest this diagnosis.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Neurosarcoidosis is a rare manifestation of sarcoidosis affecting the nervous system.
  • Diagnosis can be challenging due to the variable clinical and imaging presentations.

Purpose of the Study:

  • To describe the radiological features of biopsy-confirmed neurosarcoidosis.
  • To identify imaging patterns that may aid in the diagnosis of neurosarcoidosis.

Main Methods:

  • Retrospective review of five biopsy-confirmed cases of neurosarcoidosis.
  • Analysis of intracranial imaging, including T2-weighted and FLAIR sequences.

Main Results:

  • Imaging appearance of neurosarcoidosis is highly variable.
  • Key findings include evidence of spread along the pia mater.
  • Meningeal mass formation with specific T2/FLAIR signal characteristics (central low, peripheral high intensity) was observed.

Conclusions:

  • Neurosarcoidosis diagnosis is difficult based solely on intracranial imaging.
  • Specific imaging findings, such as pial spread and characteristic meningeal mass signal, can support the diagnosis.

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