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Visualization of mouse barrel cortex using ex-vivo track density imaging.

Nyoman D Kurniawan¹, Kay L Richards², Zhengyi Yang³

¹Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.

|September 25, 2013

Summary

Short-tracks track density imaging (stTDI) visualizes mouse brain barrel cortex structures with unprecedented clarity. This novel technique offers superior resolution compared to conventional methods, aiding sensory system research.

Keywords:

Barrel cortex CSD Constrained spherical deconvolution DEC DTI DWI Diffusion tensor imaging Diffusion weighted imaging Diffusion-weighted imaging Directionally encoded color FA FOD Fiber orientation distribution Fractional anisotropy HARDI High angular-resolution diffusion-weighted imaging Infraorbital nerve cut Magnetic resonance Mouse brain PMBSF Posterior medial barrel sub-field SH Short-tracks track density imaging Spherical harmonics TDI Track density imaging Track-density imaging VPM Ventral posteromedial thalamic nucleus stTDI

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Area of Science:

Neuroimaging
Neuroanatomy
Biophysics

Background:

The barrel cortex in the primary somatosensory area (S1) is crucial for sensory processing in rodents.
Conventional imaging techniques struggle to provide high-resolution visualization of these complex structures.

Purpose of the Study:

To introduce and evaluate short-tracks track density imaging (stTDI) for visualizing the S1 barrel cortex.
To compare stTDI's performance against established neuroimaging methods.

Main Methods:

Acquisition of 3D high angular resolution diffusion imaging (HARDI) data at 48 micron and 100 micron isotropic resolutions.
Reconstruction of HARDI data using stTDI at 10 micron and 20 micron isotropic resolutions.
Comparison of stTDI results with conventional fractional anisotropy (FA) and spin-echo/gradient echo imaging, as well as histological data.

Main Results:

stTDI achieved significantly higher definition of barrel structures than conventional imaging methods.
10 micron resolution stTDI maps provided exceptionally clear delineation of barrels.
stTDI successfully detected barrel deletions in mice with infraorbital nerve cuts, correlating with histological findings.

Conclusions:

stTDI is a novel, high-resolution imaging technique for characterizing complex brain structures like the S1 barrels.
It serves as a valuable non-invasive tool for studying sensory system connectivity, development, and plasticity.