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ERCP in the management of pancreatic diseases in children
Jaya Agarwal1, D Nageshwar Reddy1, Rupjyoti Talukdar1
1Asian Institute of Gastroenterology, Hyderabad, India.
Insights
Endoscopic retrograde cholangiopancreatography (ERCP) is a safe and effective treatment for pediatric pancreatic disorders, including chronic pancreatitis and recurrent acute pancreatitis. This study demonstrates its utility in improving symptoms and managing complications in children.
Area of Science:
- Pediatric Gastroenterology
- Interventional Endoscopy
- Pancreatic Diseases
Background:
- Experience with Endoscopic Retrograde Cholangiopancreatography (ERCP) for pediatric pancreatic disorders is limited.
- Tertiary care centers play a crucial role in managing complex pediatric gastrointestinal conditions.
Purpose of the Study:
- To evaluate the utility and efficacy of ERCP in children diagnosed with pancreatic diseases.
- To assess the safety and outcomes of ERCP procedures in a pediatric population at a referral center.
Main Methods:
- A retrospective review of consecutive pediatric patients (≤18 years) undergoing ERCP for pancreatic diseases between January 2010 and June 2011.
- Data collected included indications, procedural findings, interventions performed, adverse events, and patient outcomes.
Main Results:
- 221 ERCPs were performed in 172 children, with 83.1% diagnosed with chronic pancreatitis.
- Therapeutic interventions included sphincterotomies, pancreatic duct (PD) stenting, and common bile duct (CBD) stenting, with symptom improvement in 83% of patients.
- Procedure-related adverse events occurred in 4.7% of patients, indicating a favorable safety profile.
Conclusions:
- ERCP is a safe and effective therapeutic option for managing a range of pancreatic disorders in children.
- The findings support the use of ERCP in pediatric patients requiring intervention for conditions like chronic pancreatitis, recurrent acute pancreatitis, and pancreatic fistulas.
Background:
ERCP experience in pancreatic disorders in children is limited.
Objective:
This study evaluated the utility and efficacy of ERCP in children with pancreatic diseases at a tertiary care referral center.
Patients And Settings:
Consecutive patients 18 years of age and younger who underwent ERCP for pancreatic diseases from January 2010 to June 2011 were identified. Indications, findings, interventions, adverse events, and outcomes were recorded.
Results:
A total of 221 ERCPs were performed in 172 children (102 boys, mean ± standard deviation age 13.8 ± 3.2 years, 157 therapeutic). A total of 143 children (83.1%) had chronic pancreatitis (CP), 19 (11%) had recurrent acute pancreatitis (RAP), and 10 (5.8%) had acute pancreatitis (AP). Indications included pain (153, 89.4%), pancreatic fistula (11, 6.3%), symptomatic pseudocyst (4, 2.3%), and jaundice (3, 1.7%). In chronic pancreatitis patients, findings included a dilated and irregular main pancreatic duct (92, 64.3%), pancreatic duct (PD) calculi (76, 53%), dominant PD stricture (23, 16%), PD leak (7, 4.9%), pancreas divisum (35, 24.5%), and common bile duct (CBD) stricture (3, 2%). Therapeutic procedures included major papilla sphincterotomy (93, 65%), minor papilla sphincterotomy (32, 22.3%), PD stenting (77, 53.8%), and CBD stenting (3, 2.2%). PD stones larger than 5 mm were retrieved endoscopically after 57 extracorporeal shock wave lithotripsy sessions in 50 patients (34.9%). In patients with RAP, 6 (31.5%) had complete and 1 partial pancreas divisum. All underwent minor papillotomy. In patients with AP, 4 (40%) had stenting for PD leak, 2 (20%) underwent CBD clearance for biliary pancreatitis, and 4 (40%) had transpapillary pseudocyst drainage. During 13 ± 4.7 months (range 6-22 months) of follow-up, improvement of symptoms was seen in 143 of 172 (83%) patients. Procedure-related adverse events were seen in 8 (4.7%) patients.
Limitations:
Retrospective study.
Conclusion:
ERCP is a safe therapeutic option for pancreatic disorders in children.
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