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A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

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Sphingolipids in colon cancer.

Mónica García-Barros¹, Nicolas Coant¹, Jean-Philip Truman¹

¹Department of Medicine and the Stony Brook Cancer Center, Health Science Center, Stony Brook University, 101 Nicolls Road, T15, 023, 11794, Stony Brook, NY, USA.

Biochimica Et Biophysica Acta

|September 25, 2013

Summary

Sphingolipids, crucial bioactive lipids, are increasingly implicated in colon cancer development and progression. Understanding their role, alongside the WNT/β-catenin pathway, offers new therapeutic avenues for this deadly disease.

Keywords:

Ceramide Colorectal cancer Dietary Sphingolipids Sphingosine Sphingosine-1-phosphate

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Area of Science:

Molecular Biology
Oncology
Lipid Metabolism

Background:

Colorectal cancer remains a leading cause of mortality globally.
Current therapeutic strategies for colon cancer show limited success despite advances in understanding molecular pathways.
Sphingolipids, including ceramide, sphingosine, and sphingosine-1-phosphate, are vital bioactive lipids regulating cellular functions.

Purpose of the Study:

To review the emerging roles of endogenous and dietary sphingolipids in colon cancer.
To explore the intricate interactions between sphingolipids and the WNT/β-catenin signaling pathway.
To highlight potential therapeutic targets within sphingolipid metabolism for colon cancer treatment.

Main Methods:

Literature review of studies on sphingolipids and colon cancer.
Analysis of research on sphingolipid metabolism and its enzymes in cancer.
Examination of the cross-talk between sphingolipids and WNT/β-catenin signaling.

Main Results:

Alterations in sphingolipid levels and metabolizing enzymes are frequently observed in various cancers, including colon cancer.
Sphingolipids play multifaceted roles in colon cancer, influencing cell proliferation, survival, and migration.
The WNT/β-catenin pathway is significantly modulated by sphingolipid metabolism, impacting intestinal homeostasis and cancer development.

Conclusions:

Sphingolipids represent promising targets for novel colon cancer therapies.
Targeting sphingolipid metabolism, particularly in conjunction with the WNT/β-catenin pathway, may offer improved treatment outcomes.
Further research into dietary sphingolipids could reveal preventative or therapeutic strategies for colon cancer.