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Related Experiment Video

Updated: May 7, 2026

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

A case of mannitol hypersensitivity.

Donita D Lightner¹, Kevin De Braganca, Stephen W Gilheeney

¹Departments of *Pediatrics, Pediatric Neuro-Oncology ‡Pharmacy, Memorial Sloan-Kettering Cancer Center †Department of Pediatrics, Weill-Cornell Medical Center, New York, NY.

Journal of Pediatric Hematology/Oncology

|September 25, 2013

Summary

Mannitol is a medication used to reduce brain swelling and prevent kidney damage. This report details a rare case of anaphylaxis, a severe allergic reaction, to mannitol.

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A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (Callithrix jacchus)

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Area of Science:

Pharmacology
Clinical Medicine
Allergy and Immunology

Background:

Mannitol is a widely used osmotic diuretic.
It is indicated for managing increased intracranial pressure and preventing contrast-induced nephrotoxicity.
Adverse reactions to mannitol are uncommon.

Observation:

A case report of a patient experiencing anaphylaxis following mannitol administration.
Detailed clinical presentation and management of the anaphylactic reaction.

Findings:

Anaphylaxis is a rare but serious adverse effect of mannitol.
Prompt recognition and management are crucial for patient outcomes.

Implications:

Highlights the importance of considering anaphylaxis in patients presenting with allergic symptoms post-mannitol infusion.
Suggests the need for increased vigilance and awareness among healthcare providers regarding mannitol-induced hypersensitivity.
Contributes to the literature on rare adverse drug reactions, informing clinical practice and patient safety.