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Related Experiment Video

Updated: May 7, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Lung transplantation in patients with scleroderma.

Sharon De Cruz1, David Ross

  • 1Division of Pulmonary, Critical Care, and Sleep Medicine, University of California at Los Angeles, Los Angeles, California, USA.

Current Opinion in Rheumatology
|September 25, 2013
PubMed
Summary

Lung transplantation is a viable option for systemic sclerosis (SSc) patients with end-stage lung disease and limited organ involvement. Careful patient selection and early reflux management improve outcomes after lung transplant for SSc.

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Area of Science:

  • Immunology
  • Pulmonology
  • Transplantation Medicine

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease affecting skin and internal organs, with pulmonary complications being leading causes of death.
  • Lung transplantation in SSc patients is debated due to potential postoperative risks like reflux, renal issues, and fibrosis.

Purpose of the Study:

  • Review indications and selection criteria for lung transplantation in SSc patients.
  • Discuss single vs. bilateral lung transplantation implications.
  • Analyze post-transplant survival data in SSc.

Main Methods:

  • Literature review of studies on lung transplantation in systemic sclerosis.
  • Analysis of patient selection criteria and survival outcomes.
  • Evaluation of management strategies for SSc-related complications post-transplant.

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Last Updated: May 7, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
06:16

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Published on: May 29, 2015

Main Results:

  • Aggressive gastroesophageal reflux disease treatment enhances survival post-transplant.
  • Single lung transplantation is common for SSc patients without severe pulmonary hypertension.
  • Selected SSc patients without systemic disease show survival rates comparable to other end-stage lung disease patients.

Conclusions:

  • Lung transplantation is a feasible treatment for SSc patients with end-stage lung disease and minimal extrapulmonary involvement.
  • Careful patient selection is crucial for successful lung transplantation outcomes in SSc.